Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276535 | 0.76 | LMNA (0.43) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL6763113 | 0.66 | L3MBTL1 (0.44) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL11097773 | 0.66 | CHEK1 (0.46) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| Dipyridyl SCHEMBL27763611 | 0.66 | KDM4E (0.78) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL26051047 | 0.65 | KDM4E (0.43) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL14341067 | 0.63 | KDM4E (0.56) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4777973 | 0.63 | KDM4E (0.50) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| Dipyridyl SCHEMBL28457942 | 0.62 | KDM4E (0.70) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| Dipyridyl SCHEMBL5974690 | 0.62 | KDM4E (0.70) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 | |
| Dipyridyl SCHEMBL2026660 | 0.62 | KDM4E (0.70) | LMNAL3MBTL1ALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0222358-B1 | CARDIOTONIC HETEROCYCLIC OXAZOLONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-17 | — | — | EP | disclosed |
| US-4698353-A | REDUCED TOXICITY | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-10-06 | — | — | US | disclosed |
| EP-0222358-A1 | Cardiotonic heterocyclic oxazolones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-05-20 | — | — | EP | disclosed |