Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | AGTR1 | P30556 | 4/20 | 0.59 |
| ▸ | DRD4 | P21917 | 1/20 | 0.59 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9347486 | 0.79 | PKM (0.43) | CYP3A4CYP2D6CYP2C9ALOX15TSHR | |
| SCHEMBL7286312 | 0.76 | CYP3A4 (0.74) | CYP3A4CYP2D6CYP2C9ALOX15TSHR | |
| SCHEMBL29394266 | 0.76 | CYP3A4 (0.74) | CYP3A4CYP2D6CYP2C9ALOX15TSHR | |
| SCHEMBL9495156 | 0.76 | AGTR1 (0.56) | CYP3A4CYP2D6CYP2C9CYP2C19AGTR1 | |
| Hydrochloric Acid SCHEMBL7286126 | 0.76 | AGTR1 (0.75) | CYP3A4CYP2D6CYP2C9ALOX15TSHR | |
| SCHEMBL9140085 | 0.75 | AGTR1 (0.56) | AGTR1PKMSMN1; SMN2AGTR2PTGS2 | |
| SCHEMBL9494031 | 0.75 | AGTR1 (0.59) | CYP3A4CYP2D6CYP2C9CYP2C19AGTR1 | |
| SCHEMBL9495149 | 0.73 | SMN1; SMN2 (0.45) | AGTR1PKMSMN1; SMN2AGTR2PTGS2 | |
| SCHEMBL7274695 | 0.73 | CYP3A4 (0.68) | CYP3A4CYP2D6CYP2C9ALOX15TSHR | |
| SCHEMBL9494023 | 0.72 | SMN1; SMN2 (0.43) | CYP3A4CYP2C9CYP2C19AGTR1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516392-B1 | Naphthyridine derivatives as angiotensin II inhibitors | ASTRAZENECA AB (SE) | 2001-08-29 | — | — | EP | disclosed |
| US-5294620-A | Hypotensive agents or compounds for cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-03-15 | — | — | US | disclosed |
| US-5217976-A | Hypotensive agents, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |
| EP-0516392-A2 | Naphthyridine derivatives as angiotensin II inhibitors | ZENECA LIMITED (GB) | 1992-12-02 | — | — | EP | disclosed |