Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326544 | 0.85 | CTSK (0.42) | CTSKMAPTXBP1NPSR1TDP1 | |
| SCHEMBL7373003 | 0.84 | RAB9A (0.41) | CTSKMAPTXBP1NPSR1TDP1 | |
| SCHEMBL5093810 | 0.84 | RAB9A (0.41) | CTSKMAPTXBP1NPSR1TDP1 | |
| SCHEMBL9329333 | 0.81 | CTSB (0.43) | CTSKMAPTXBP1NPSR1TDP1 | |
| SCHEMBL9327794 | 0.81 | RAB9A (0.39) | CTSKMAPTXBP1NPSR1TDP1 | |
| SCHEMBL9326476 | 0.81 | MAPT (0.43) | CTSKMAPTXBP1NPSR1TDP1 | |
| SCHEMBL9326520 | 0.80 | CTSK (0.39) | CTSKMAPTXBP1NPSR1TDP1 | |
| SCHEMBL9326565 | 0.80 | CTSK (0.39) | CTSKMAPTXBP1NPSR1TDP1 | |
| SCHEMBL7405620 | 0.78 | RAB9A (0.42) | CTSKMAPTMEN1KMT2ASYK | |
| SCHEMBL7405615 | 0.78 | RAB9A (0.42) | CTSKMAPTMEN1KMT2ASYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574758-B1 | Hydroxamic acid derivatives as collagenase inhibitors | HOFFMANN LA ROCHE (CH) | 1998-09-09 | — | — | EP | disclosed |
| US-5447929-A | Collagenase inhibitors for degenerative joint disease, antitumor agents or atherosclerosis | HOFFMANN-LA ROCHE INC. (US) | 1995-09-05 | — | — | US | disclosed |
| US-5318964-A | Collangenase inhibitors; antiarthritic and -tumor agents; rheumatic diseases; osteoarthritis; atherosclerosis; multiple sclerosis | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0574758-A1 | Hydroxamic acid derivatives as collagenase inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1993-12-22 | — | — | EP | disclosed |