Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 19/20 | 0.55 |
| ▸ | CTRC | Q99895 | 3/20 | 0.55 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6282557 | 0.93 | ELANE (0.59) | ELANECTRC | |
| SCHEMBL8536676 | 0.85 | ELANE (0.59) | ELANECTRCMGLL | |
| SCHEMBL7289416 | 0.84 | ELANE (0.64) | ELANECTRC | |
| SCHEMBL7446091 | 0.83 | ELANE (0.53) | ELANECTRCMGLL | |
| SCHEMBL7277028 | 0.82 | ELANE (0.46) | ELANECTRC | |
| SCHEMBL7274678 | 0.82 | HDAC3 (0.49) | ELANECTRC | |
| SCHEMBL7276488 | 0.77 | ELANE (0.64) | ELANECTRC | |
| SCHEMBL6086170 | 0.77 | ELANE (0.62) | ELANECTRC | |
| SCHEMBL7442027 | 0.76 | ELANE (0.64) | ELANECTRC | |
| SCHEMBL6557643 | 0.75 | ELANE (0.64) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636142-B1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LTD (GB) | 1998-06-17 | — | — | EP | disclosed |
| US-5721222-A | Heterocyclic ketones | ZENECA LIMITED (GB) | 1998-02-24 | — | — | US | disclosed |
| US-5486529-A | Certain pyridyl ketones for treating diseases involving leukocyte elastase | ZENECA LIMITED (GB) | 1996-01-23 | — | — | US | disclosed |
| EP-0636142-A1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LIMITED (GB) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021209-A1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |