Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 18/20 | 0.59 |
| ▸ | CTRC | Q99895 | 3/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440440 | 0.93 | ELANE (0.55) | ELANECTRC | |
| SCHEMBL7289416 | 0.91 | ELANE (0.64) | ELANECTRC | |
| SCHEMBL7277028 | 0.86 | ELANE (0.46) | ELANECTRCCASP1NPC1RAB9A | |
| SCHEMBL7274678 | 0.86 | HDAC3 (0.49) | ELANECTRCCASP1NPC1RAB9A | |
| SCHEMBL7276488 | 0.83 | ELANE (0.64) | ELANECTRCCASP1NPC1RAB9A | |
| SCHEMBL6086170 | 0.82 | ELANE (0.62) | ELANECTRCNPC1RAB9A | |
| SCHEMBL7283751 | 0.81 | ELANE (0.57) | ELANECTRCCASP1NPC1RAB9A | |
| SCHEMBL7301356 | 0.78 | ELANE (0.64) | ELANE | |
| SCHEMBL8536676 | 0.77 | ELANE (0.59) | ELANECTRC | |
| SCHEMBL7284339 | 0.75 | ELANE (0.80) | ELANECTRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6906068-B1 | Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants | PHARMACIA CORPORATION (US) | 2005-06-14 | — | — | US | disclosed |
| EP-0636142-B1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LTD (GB) | 1998-06-17 | — | — | EP | disclosed |
| EP-0509769-B1 | Heterocyclic amides having HLE inhibiting activity | ZENECA LTD (GB) | 1996-09-11 | — | — | EP | disclosed |
| US-5521179-A | Heterocyclic amides | ZENECA LIMITED (GB) | 1996-05-28 | — | — | US | disclosed |
| EP-0636142-A1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LIMITED (GB) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021209-A1 | LACTAM PEPTIDES HAVING HLE INHIBITING ACTIVITY | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |
| WO-1993021213-A1 | ALPHA-AMINOBORONIC ACID PEPTIDES AND THEIR USE AS ELASTASE INHIBITORS | ZENECA LIMITED (GB) | 1993-10-28 | — | — | WO | disclosed |
| EP-0509769-A2 | Heterocyclic amides having HLE inhibiting activity | ZENECA LIMITED (GB) | 1992-10-21 | — | — | EP | disclosed |