Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 13/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 11/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | QPCT | Q16769 | 1/20 | 0.46 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.46 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5456305 | 0.82 | TBXAS1 (0.46) | ALOX15CYP19A1TBXAS1KMT2A | |
| SCHEMBL27835626 | 0.80 | TAAR1 (0.40) | ALOX15CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL8541930 | 0.77 | TBXAS1 (0.58) | TBXAS1MEN1KMT2A | |
| SCHEMBL27228606 | 0.75 | TBXAS1 (0.36) | ALOX15CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL28065473 | 0.75 | ALDH1A1 (0.40) | ALOX15CYP11B1CYP11B2CYP19A1TBXAS1 | |
| SCHEMBL28474546 | 0.74 | TP53 (0.40) | CYP19A1TBXAS1 | |
| SCHEMBL23206014 | 0.73 | ALOX15 (0.50) | ALOX15SMN1; SMN2 | |
| SCHEMBL13105237 | 0.71 | CYP11B1 (0.72) | CYP11B1CYP11B2CYP19A1TBXAS1CYP1A2 | |
| SCHEMBL5456302 | 0.70 | TBXAS1 (0.36) | CYP11B1CYP11B2CYP19A1TBXAS1CYP1A2 | |
| 1-Methylimidazole SCHEMBL29204938 | 0.69 | NFKB1 (0.48) | ALOX15CYP19A1TBXAS1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025489-A | Tricyclic pteridinones and a process for their preparation | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-15 | — | — | US | disclosed |
| EP-0429149-B1 | Tricyclic pteridinones and a process for their preparation | BERLEX LAB (US) | 2000-01-05 | — | — | EP | disclosed |
| EP-0400583-B1 | Imidazoquinoxalinones, their aza analogs and process for their preparation | BERLEX LAB (US) | 1999-11-17 | — | — | EP | disclosed |
| US-5854419-A | Tricyclic pteridinones and a process for their preparation | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-12-29 | — | — | US | disclosed |
| US-5807880-A | ANTICANCER AGENTS; DISEASES OF PROSTATE GLAND, MAMMARY GLANDS; ENDOMETRIOSIS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1998-09-15 | — | — | US | disclosed |
| US-5602252-A | Tricyclic pteridinones and a process for their preparation | BERLEX LABORATORIES, INC. | 1997-02-11 | — | — | US | disclosed |
| EP-0721943-A1 | AZOLE DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1996-07-17 | — | — | EP | disclosed |
| US-5166344-A | Process for the preparation of imidazoquinoxalinones | BERLEX LABORATORIES, INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5055465-A | IMIDAZOQUINOXALINONES, THEIR AZA ANALOGS AND PROCESS FOR THEIR PREPARATION | BERLEX LABORATORIES, INC. (US) | 1991-10-08 | — | — | US | disclosed |
| EP-0429149-A1 | Tricyclic pteridinones and a process for their preparation | BERLEX LABORATORIES, INC. (US) | 1991-05-29 | — | — | EP | disclosed |
| EP-0400583-A1 | Imidazoquinoxalinones, their aza analogs and process for their preparation | BERLEX LABORATORIES, INC. (US) | 1990-12-05 | — | — | EP | disclosed |