Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269860 | 0.82 | PCSK9 (0.47) | GAAMEN1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL1526122 | 0.74 | KCNA5 (0.50) | SMN1; SMN2LMNAGAAMEN1KMT2A | |
| SCHEMBL7275282 | 0.74 | KCNA5 (0.50) | SMN1; SMN2LMNAGAAMEN1KMT2A | |
| SCHEMBL7545282 | 0.73 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL8203981 | 0.73 | L3MBTL1 (0.46) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 | |
| SCHEMBL8192518 | 0.73 | L3MBTL1 (0.46) | SMN1; SMN2NPC1RAB9ALMNAL3MBTL1 | |
| SCHEMBL9773746 | 0.73 | ACHE (0.44) | SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL7293012 | 0.72 | KCNA5 (0.49) | SMN1; SMN2NPC1RAB9ALMNAGAA | |
| SCHEMBL8986648 | 0.72 | KCNA5 (0.49) | SMN1; SMN2NPC1RAB9ALMNAGAA | |
| SCHEMBL7440314 | 0.72 | HRH4 (0.46) | SMN1; SMN2NPC1RAB9ALMNAHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376040-A2 | N-phosphinyl di-and tripeptides as renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |