Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.55 |
| ▸ | ANPEP | P15144 | 2/20 | 0.51 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.51 |
| ▸ | DNPEP | Q9ULA0 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 3/20 | 0.44 |
| ▸ | CPA3 | P15088 | 1/20 | 0.44 |
| ▸ | LAP3 | P28838 | 2/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3039933 | 0.85 | MTNR1A (0.55) | MTNR1AMTNR1BANPEPRNPEPDNPEP | |
| SCHEMBL3055735 | 0.85 | MTNR1A (0.55) | MTNR1AMTNR1BANPEPRNPEPDNPEP | |
| SCHEMBL6692780 | 0.78 | MTNR1A (0.58) | MTNR1AMTNR1BANPEPRNPEPDNPEP | |
| SCHEMBL7428008 | 0.78 | MTNR1A (0.58) | MTNR1AMTNR1BANPEPRNPEPDNPEP | |
| SCHEMBL3039937 | 0.77 | MTNR1A (0.57) | MTNR1AMTNR1BANPEPRNPEPDNPEP | |
| SCHEMBL3055737 | 0.77 | MTNR1A (0.57) | MTNR1AMTNR1BANPEPRNPEPDNPEP | |
| SCHEMBL620307 | 0.75 | CYP1A2 (0.64) | CYP1A2CPA3 | |
| SCHEMBL7277572 | 0.75 | CYP1A2 (0.50) | CYP1A2CPA3 | |
| SCHEMBL1709763 | 0.74 | MTNR1A (0.64) | MTNR1AMTNR1BCYP1A2CTRB1MME | |
| Acetamide SCHEMBL7277641 | 0.73 | CYP1A2 (0.56) | ANPEPRNPEPDNPEPCYP1A2CPA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4766110-A | INHIBITS ANGIOTENSIN CONVERTING ENZYME, HYPOTENSIVE AGENTS | RYAN JAMES W (US) | 1988-08-23 | — | — | US | disclosed |
| EP-0073143-B1 | NOVEL COMPLEX AMIDO AND IMIDO DERIVATIVES OF CARBOXYALKYL PEPTIDES AND THIOETHERS AND ETHERS OF PEPTIDES | Ryan, James Walter (US) | 1985-11-21 | — | — | EP | disclosed |
| US-4472380-A | CARBOXYALKYL DIPEPTIDE DERIVATIVES | MERCK & CO., INC. (US) | 1984-09-18 | — | — | US | disclosed |
| EP-0073143-A2 | Novel complex amido and imido derivatives of carboxyalkyl peptides and thioethers and ethers of peptides | Ryan, James Walter (US) | 1983-03-02 | — | — | EP | disclosed |
| US-4374829-A | Aminoacid derivatives as antihypertensives | MERCK & CO., INC. (US) | 1983-02-22 | — | — | US | disclosed |
| EP-0048159-A2 | Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents | UNIVERSITY OF MIAMI (US) | 1982-03-24 | — | — | EP | disclosed |
| EP-0012401-A1 | Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1980-06-25 | — | — | EP | disclosed |