Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.62 |
| ▸ | DRD2 | P14416 | 3/20 | 0.61 |
| ▸ | HTR2A | P28223 | 3/20 | 0.61 |
| ▸ | HTR2C | P28335 | 3/20 | 0.61 |
| ▸ | HTR2B | P41595 | 3/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CCR5 | P51681 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7269086 | 0.89 | OPRM1 (0.72) | KCNH2OPRM1SIGMAR1DRD2HTR2A | |
| SCHEMBL13478882 | 0.89 | KCNH2 (0.67) | KCNH2OPRM1SIGMAR1DRD2HTR2A | |
| SCHEMBL5116528 | 0.86 | KCNH2 (0.67) | KCNH2OPRM1SIGMAR1DRD2HTR2A | |
| SCHEMBL2845483 | 0.85 | KCNH2 (0.65) | KCNH2OPRM1SIGMAR1DRD2HTR2A | |
| SCHEMBL784863 | 0.85 | SIGMAR1 (0.68) | KCNH2OPRM1SIGMAR1DRD2HTR2A | |
| SCHEMBL19734931 | 0.84 | OPRM1 (0.58) | KCNH2OPRM1SIGMAR1DRD2HTR2A | |
| SCHEMBL9030647 | 0.83 | SIGMAR1 (0.67) | KCNH2OPRM1SIGMAR1DRD2HTR2A | |
| SCHEMBL9472071 | 0.83 | SIGMAR1 (0.60) | KCNH2OPRM1SIGMAR1DRD2HTR2A | |
| SCHEMBL11313073 | 0.82 | SIGMAR1 (0.65) | KCNH2OPRM1SIGMAR1DRD2HTR2A | |
| SCHEMBL27473621 | 0.82 | SIGMAR1 (0.65) | KCNH2OPRM1SIGMAR1DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457686-B1 | Novel aminopiperidine, aminopyrrolidine and aminoperhydroazepine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1994-08-03 | — | — | EP | disclosed |
| US-5214055-A | Analgesics, psychological disorders, anxiolytic agents | ADIR ET COMPAGNIE (FR) | 1993-05-25 | — | — | US | disclosed |
| US-5189045-A | Antiserotonine agent | ADIR ET COMPAGNIE (FR) | 1993-02-23 | — | — | US | disclosed |
| EP-0457686-A1 | Novel aminopiperidine, aminopyrrolidine and aminoperhydroazepine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-11-21 | — | — | EP | disclosed |