Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.68 |
| ▸ | HTR2A | P28223 | 4/20 | 0.68 |
| ▸ | HTR2C | P28335 | 4/20 | 0.68 |
| ▸ | HTR2B | P41595 | 4/20 | 0.68 |
| ▸ | DRD2 | P14416 | 3/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.63 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.63 |
| ▸ | ACHE | P22303 | 2/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3942391 | 0.92 | CHRM4 (0.62) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL3817982 | 0.91 | OPRM1 (0.59) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL1220330 | 0.91 | OPRM1 (0.59) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| Hydrochloric Acid SCHEMBL4469375 | 0.90 | OPRM1 (0.57) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| Hydrochloric Acid SCHEMBL4469376 | 0.90 | OPRM1 (0.57) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL9030647 | 0.90 | SIGMAR1 (0.67) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL11313073 | 0.88 | SIGMAR1 (0.65) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL3593317 | 0.88 | SIGMAR1 (0.55) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL27473621 | 0.88 | SIGMAR1 (0.65) | SIGMAR1HTR2AHTR2CHTR2BDRD2 | |
| SCHEMBL7269086 | 0.87 | OPRM1 (0.72) | SIGMAR1HTR2AHTR2CHTR2BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| EP-2619178-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
| EP-0457686-B1 | Novel aminopiperidine, aminopyrrolidine and aminoperhydroazepine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1994-08-03 | — | — | EP | disclosed |
| EP-0457686-A1 | Novel aminopiperidine, aminopyrrolidine and aminoperhydroazepine derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071461-A1 | Substituted Benzamide Compounds | BDKRB1, BDKRB2, HRH2 | SIGMAR1 369/4885HTR2A 475/4885HTR2C 549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.