Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28363958 | 0.88 | TSHR (0.54) | TSHRKMT2AMEN1GAATDP1 | |
| SCHEMBL2433806 | 0.86 | TSHR (0.38) | TSHRKMT2AMEN1GAATDP1 | |
| SCHEMBL7119549 | 0.84 | TDP1 (0.50) | TSHRKMT2AMEN1GAATDP1 | |
| SCHEMBL1638343 | 0.84 | CTSK (0.43) | KMT2AMEN1GAATDP1CA2 | |
| SCHEMBL4653239 | 0.83 | DGKA (0.43) | TSHRTDP1CA1CA7CA12 | |
| SCHEMBL28651273 | 0.83 | HDAC4 (0.40) | TSHRKMT2AMEN1GAATDP1 | |
| SCHEMBL9753571 | 0.83 | TDP1 (0.38) | TSHRKMT2AMEN1GAATDP1 | |
| SCHEMBL5354850 | 0.82 | CA2 (0.41) | TSHRKMT2AMEN1GAATDP1 | |
| SCHEMBL28609057 | 0.82 | EPHX2 (0.35) | KMT2AMEN1GAATDP1CA2 | |
| SCHEMBL28919420 | 0.82 | MAPT (0.39) | KMT2AMEN1GAATDP1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0290211-B1 | DIHYDROPYRIDINES | Pfizer Limited (GB) | 1991-09-04 | — | — | EP | disclosed |
| EP-0290211-A1 | Dihydropyridines | Pfizer Limited (GB) | 1988-11-09 | — | — | EP | disclosed |