Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CASP1 | P29466 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7282267 | 0.74 | GAA (0.41) | POLBLMNAKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7280348 | 0.67 | HSD17B10 (0.48) | POLBSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL7289643 | 0.67 | PDE4A (0.59) | SMN1; SMN2LMNAKDM4EALDH1A1HPGD | |
| SCHEMBL5773802 | 0.66 | NPY5R (0.49) | POLBMAPK1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL8551939 | 0.65 | ALDH1A1 (0.48) | POLBSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL20509943 | 0.65 | POLB (0.51) | POLBMAPK1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7281409 | 0.65 | KMT2A (0.52) | POLBSMN1; SMN2LMNAKDM4EALDH1A1 | |
| SCHEMBL7291598 | 0.64 | KDM4E (0.47) | SMN1; SMN2LMNAKDM4EALDH1A1HSD17B10 | |
| SCHEMBL19956900 | 0.63 | KDM4E (0.49) | POLBMAPK1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL17344005 | 0.62 | LMNA (0.84) | POLBSMN1; SMN2LMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4505910-A | Amino-pyrimidine derivatives, compositions and use | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-03-19 | — | — | US | claimed |
| EP-0130735-A1 | Amino-pyrimidine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-01-09 | — | — | EP | claimed |
| US-4505910-A | Amino-pyrimidine derivatives, compositions and use | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-03-19 | — | — | US | disclosed |
| EP-0130735-A1 | Amino-pyrimidine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-01-09 | — | — | EP | disclosed |