Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.84 |
| ▸ | KDM4E | B2RXH2 | 15/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.62 |
| ▸ | HPGD | P15428 | 9/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24256420 | 0.70 | KDM4E (0.73) | LMNAKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL17344002 | 0.66 | ALDH1A1 (1.00) | LMNAKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL12655045 | 0.65 | TLR9 (0.58) | LMNASMN1; SMN2GAAMAPTTSHR | |
| SCHEMBL24256416 | 0.65 | KDM4E (0.66) | LMNAKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL24256417 | 0.65 | KDM4E (0.71) | LMNAKDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL24256904 | 0.65 | L3MBTL1 (0.83) | LMNAKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL6955347 | 0.64 | LMNA (0.51) | LMNAKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL6444222 | 0.64 | ALDH1A1 (0.63) | LMNAKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL6445232 | 0.64 | ACHE (0.56) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL24324971 | 0.62 | SIGMAR1 (0.47) | LMNAKDM4EMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150361046-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR3 | MERCK PATENT GMBH (DE) | 2015-12-17 | — | — | US | disclosed |
| US-20150361046-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR3 | MERCK PATENT GMBH (DE) | 2015-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150361046-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR3 | GRM3, GRM1, GRM4 | LMNA 4761/4885KDM4E 1126/4885ALDH1A1 4723/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.