Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 9/20 | 0.47 |
| ▸ | TAS1R1 | Q7RTX1 | 9/20 | 0.47 |
| ▸ | BIRC2 | Q13490 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7279383 | 1.00 | FOLH1 (0.47) | FOLH1TAS1R3TAS1R1BIRC2POLB | |
| SCHEMBL6444952 | 0.87 | ALDH1A1 (0.53) | FOLH1MME | |
| SCHEMBL6444948 | 0.87 | ALDH1A1 (0.53) | FOLH1MME | |
| SCHEMBL30174611 | 0.85 | BIRC2 (0.54) | FOLH1TAS1R3TAS1R1BIRC2 | |
| SCHEMBL7751184 | 0.82 | TAS1R3 (0.54) | FOLH1TAS1R3TAS1R1BIRC2POLB | |
| SCHEMBL11434953 | 0.82 | TAS1R3 (0.54) | FOLH1TAS1R3TAS1R1BIRC2POLB | |
| SCHEMBL14958646 | 0.80 | FOLH1 (0.42) | FOLH1TAS1R3TAS1R1BIRC2POLB | |
| SCHEMBL7365210 | 0.79 | TAS1R3 (0.46) | FOLH1TAS1R3TAS1R1BIRC2POLB | |
| SCHEMBL7365213 | 0.79 | TAS1R3 (0.46) | FOLH1TAS1R3TAS1R1BIRC2POLB | |
| SCHEMBL7328622 | 0.79 | TAS1R3 (0.46) | FOLH1TAS1R3TAS1R1BIRC2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839798-A2 | Intermediates for preparating non-peptide retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1998-05-06 | — | — | EP | disclosed |
| US-5670675-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-09-23 | — | — | US | disclosed |
| US-5545750-A | TREATING HUMAN IMMUNODEFICIENCY VIRUS | ABBOTT LABORATORIES (US) | 1996-08-13 | — | — | US | disclosed |
| US-5142056-A | Human immunodeficiency virus protease inhibitor | ABBOTT LABORATORIES (US) | 1992-08-25 | — | — | US | disclosed |
| EP-0415981-A4 | RETROVIRAL PROTEASE INHIBITORS | — | 1991-10-09 | — | — | EP | disclosed |
| EP-0415981-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| EP-0402646-A1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1990-12-19 | — | — | EP | disclosed |
| EP-0342541-A2 | Retroviral protease inhibitors | ABBOTT LABORATORIES (US) | 1989-11-23 | — | — | EP | disclosed |
| WO-1989010752-A1 | RETROVIRAL PROTEASE INHIBITORS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |