Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7281310 | 0.92 | MAPT (0.49) | MAPTKMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL11719282 | 0.83 | MAPT (0.68) | MAPTKMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL4578627 | 0.83 | MAPT (0.68) | MAPTKMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL9142116 | 0.82 | KMT2A (0.64) | MAPTKMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL9142228 | 0.82 | MAPT (0.60) | MAPTKMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL7288432 | 0.78 | MEN1 (0.69) | MAPTKMT2AMEN1LMNAHTT | |
| SCHEMBL29286032 | 0.78 | ALDH1A1 (0.55) | MAPTKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9140220 | 0.77 | MAPT (0.55) | MAPTKMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL7282602 | 0.76 | MEN1 (0.56) | MAPTKMT2AMEN1POLBLMNA | |
| SCHEMBL7279868 | 0.76 | CYP2D6 (0.46) | MAPTKMT2AMEN1SCN5ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567264-A | ADRENERGIC BLOCKING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1986-01-28 | — | — | US | disclosed |
| EP-0126449-A1 | Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry | SYNTEX (U.S.A.) INC. (US) | 1984-11-28 | — | — | EP | disclosed |