Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7279122 | 0.76 | F2 (0.37) | ALOX15TSHRCASP1LMNATP53 | |
| SCHEMBL7279628 | 0.75 | ELANE (0.50) | ALOX15TSHRCASP1LMNATP53 | |
| Trifluoromethanesulfonic Acid SCHEMBL7286712 | 0.74 | HTT (0.34) | TSHRNPSR1F2 | |
| SCHEMBL7286342 | 0.73 | LMNA (0.41) | ALOX15TSHRLMNATP53USP2 | |
| SCHEMBL7285854 | 0.72 | ALOX15 (0.58) | ALOX15TSHRCASP1LMNATP53 | |
| SCHEMBL7286277 | 0.71 | ELANE (0.39) | TSHRLMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL6860344 | 0.71 | ELANE (0.39) | TSHRLMNASMN1; SMN2MAPTMAPK1 | |
| SCHEMBL7286039 | 0.71 | ELANE (0.52) | CASP1HSD17B10 | |
| SCHEMBL7860987 | 0.70 | ELANE (0.37) | — | |
| SCHEMBL8939655 | 0.70 | F2 (0.47) | F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291234-B1 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5164371-A | HETEROCYCLIC KETONES | ICI AMERICAS INC. (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0291234-A2 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC. (US) | 1988-11-17 | — | — | EP | disclosed |