⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6700786 | 0.85 | TSHR (0.35) | — | |
| SCHEMBL8634083 | 0.82 | ALDH1A1 (0.33) | — | |
| SCHEMBL17789995 | 0.80 | ALDH1A1 (0.32) | — | |
| SCHEMBL3305382 | 0.79 | — | — | |
| SCHEMBL10964227 | 0.79 | — | — | |
| SCHEMBL274489 | 0.79 | LMNA (0.42) | — | |
| SCHEMBL11790349 | 0.78 | ALDH1A1 (0.31) | — | |
| SCHEMBL11503836 | 0.78 | ALDH1A1 (0.31) | — | |
| Di(Hydroxyethyl)Ether SCHEMBL8068984 | 0.75 | TSHR (0.53) | — | |
| SCHEMBL8099939 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0406502-B1 | Process for the preparation of (-)2-(2-(2-aminoethoxy)ethoxy)methyl)-4-(2, 3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine, and intermediate for its preparation | ADIR (FR) | 1995-05-10 | — | — | EP | claimed |
| EP-0406502-A1 | Process for the preparation of (-)2-(2-(2-aminoethoxy)ethoxy)methyl)-4-(2, 3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine, and intermediate for its preparation | ADIR ET COMPAGNIE (FR) | 1991-01-09 | — | — | EP | claimed |
| EP-0406502-B1 | Process for the preparation of (-)2-(2-(2-aminoethoxy)ethoxy)methyl)-4-(2, 3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine, and intermediate for its preparation | ADIR (FR) | 1995-05-10 | — | — | EP | disclosed |
| EP-0419297-B1 | Process for the separation of optical isomers from 1,4-dihydropyridine derivatives | ADIR (FR) | 1994-06-08 | — | — | EP | disclosed |
| EP-0419297-A1 | Process for the separation of optical isomers from 1,4-dihydropyridine derivatives | ADIR ET COMPAGNIE (FR) | 1991-03-27 | — | — | EP | disclosed |
| EP-0406502-A1 | Process for the preparation of (-)2-(2-(2-aminoethoxy)ethoxy)methyl)-4-(2, 3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine, and intermediate for its preparation | ADIR ET COMPAGNIE (FR) | 1991-01-09 | — | — | EP | disclosed |