Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 3/20 | 0.47 |
| ▸ | PRTN3 | P24158 | 2/20 | 0.47 |
| ▸ | CTSK | P43235 | 4/20 | 0.46 |
| ▸ | CTSL | P07711 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.46 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.45 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4394496 | 0.91 | ATM (0.56) | ELANEATMCTSBPRTN3CTSK | |
| SCHEMBL4394493 | 0.91 | ATM (0.56) | ELANEATMCTSBPRTN3CTSK | |
| SCHEMBL2228854 | 0.91 | ATM (0.56) | ELANEATMCTSBPRTN3CTSK | |
| SCHEMBL7307323 | 0.82 | CTSL (0.58) | ELANEATMCTSBCTSKCTSL | |
| SCHEMBL10557675 | 0.82 | CTRB1 (0.51) | ELANEATMCTSBCTSKCTSL | |
| SCHEMBL7807991 | 0.81 | CASP3 (0.59) | CTSBCTSKCTSLCTSSCASP1 | |
| SCHEMBL7807995 | 0.81 | CASP3 (0.59) | CTSBCTSKCTSLCTSSCASP1 | |
| SCHEMBL10421380 | 0.81 | ELANE (0.49) | ELANEATMCTSBPRTN3CTSK | |
| SCHEMBL11185055 | 0.80 | HSD17B10 (0.48) | ATMCTSBCTSKCTSLCTSS | |
| SCHEMBL14341586 | 0.80 | CTSL (0.63) | CTSBCTSKCTSLCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248562-B1 | Difluoro peptide compounds | ZENECA INC (US) | 1995-10-25 | — | — | EP | disclosed |
| EP-0291234-B1 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5164371-A | HETEROCYCLIC KETONES | ICI AMERICAS INC. (US) | 1992-11-17 | — | — | US | disclosed |
| EP-0249349-B1 | DIFLUOROKETO COMPOUNDS | ICI AMERICAS INC. (US) | 1992-10-14 | — | — | EP | disclosed |
| US-4923890-A | Difluoro keto compounds and their use as HLE inhibitors | ICI AMERICAS INC. (US) | 1990-05-08 | — | — | US | disclosed |
| US-4873221-A | Difluoro peptide compounds | ICI AMERICAS INC. (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0291234-A2 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC. (US) | 1988-11-17 | — | — | EP | disclosed |
| EP-0249349-A1 | Difluoroketo compounds | ICI AMERICAS INC. (US) | 1987-12-16 | — | — | EP | disclosed |
| EP-0248562-A2 | Difluoro peptide compounds | ZENECA INC. (US) | 1987-12-09 | — | — | EP | disclosed |
| US-4691007-A | HUMAN LEUKOCYTE ELASTASE INHIBITORS | ICI AMERICAS INC. (US) | 1987-09-01 | — | — | US | disclosed |
| EP-0204571-A2 | Selected difluoro derivatives | ICI AMERICAS INC. (US) | 1986-12-10 | — | — | EP | disclosed |
| US-4596789-A | Pharmaceuticals | ICI AMERICAS INC. (US) | 1986-06-24 | — | — | US | disclosed |
| EP-0124317-A2 | Proline derivatives | ICI AMERICAS INC. (US) | 1984-11-07 | — | — | EP | disclosed |