Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2106319 | 0.88 | — | — | |
| SCHEMBL6580205 | 0.79 | KMT2A (0.48) | KMT2AMEN1POLBCHRM2CHRM4 | |
| SCHEMBL16116449 | 0.77 | — | — | |
| SCHEMBL4531618 | 0.75 | MEN1 (0.55) | KMT2AMEN1POLBCHRM2CHRM4 | |
| SCHEMBL11052023 | 0.74 | MEN1 (0.53) | KMT2AMEN1POLBBRD4BRD2 | |
| SCHEMBL719466 | 0.72 | F2 (0.48) | KMT2AMEN1POLBCHRM2CHRM4 | |
| SCHEMBL6044381 | 0.72 | KMT2A (0.42) | KMT2AMEN1POLBCHRM2CHRM4 | |
| SCHEMBL10799321 | 0.72 | KMT2A (0.42) | KMT2AMEN1POLBCHRM2CHRM4 | |
| SCHEMBL8282999 | 0.72 | KMT2A (0.42) | KMT2AMEN1POLBCHRM2CHRM4 | |
| SCHEMBL9344572 | 0.72 | KMT2A (0.42) | KMT2AMEN1POLBCHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0574758-B1 | Hydroxamic acid derivatives as collagenase inhibitors | HOFFMANN LA ROCHE (CH) | 1998-09-09 | — | — | EP | disclosed |
| US-5447929-A | Collagenase inhibitors for degenerative joint disease, antitumor agents or atherosclerosis | HOFFMANN-LA ROCHE INC. (US) | 1995-09-05 | — | — | US | disclosed |
| US-5318964-A | Collangenase inhibitors; antiarthritic and -tumor agents; rheumatic diseases; osteoarthritis; atherosclerosis; multiple sclerosis | HOFFMANN-LA ROCHE INC. (US) | 1994-06-07 | — | — | US | disclosed |
| EP-0574758-A1 | Hydroxamic acid derivatives as collagenase inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1993-12-22 | — | — | EP | disclosed |
| US-4629683-A | STORAGE STABILITY AND TIMELY RELEASE OF PHOTOGRAPHICALLY USEFUL AGENT | FUJI PHOTO FILM CO., LTD. (JP) | 1986-12-16 | — | — | US | disclosed |