Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HEXA | P06865 | 1/20 | 0.34 |
| ▸ | HEXB | P07686 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280211 | 1.00 | KMT2A (0.34) | KMT2AHEXAHEXBKDM4EMEN1 | |
| SCHEMBL7272766 | 0.83 | ALDH1A1 (0.37) | KMT2AHEXAHEXBKDM4ENPC1 | |
| SCHEMBL7272773 | 0.83 | ALDH1A1 (0.37) | KMT2AHEXAHEXBKDM4ENPC1 | |
| SCHEMBL9848568 | 0.78 | CSNK1A1 (0.41) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL9848576 | 0.78 | CSNK1A1 (0.41) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL7271143 | 0.77 | HEXA (0.42) | KMT2AHEXAHEXBMEN1NPC1 | |
| SCHEMBL7271200 | 0.77 | HEXA (0.42) | KMT2AHEXAHEXBMEN1NPC1 | |
| SCHEMBL7280636 | 0.76 | DHFR (0.52) | KMT2AKDM4EALDH1A1DHFR | |
| SCHEMBL6049569 | 0.73 | DHFR (0.46) | KMT2AHEXAHEXBMEN1ALDH1A1 | |
| SCHEMBL11133814 | 0.71 | KMT2A (0.47) | KMT2AKDM4EMEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0679645-A1 | Pharmacologically active CNS pyridmidin compounds | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-11-02 | — | — | EP | disclosed |
| EP-0459819-A2 | Pharmacologically active CNS compound | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-04 | — | — | EP | disclosed |