Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 13/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | CTSE | P14091 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299470 | 0.85 | CTSS (0.41) | CTSSCTSKAAK1RENCTSD | |
| SCHEMBL7280379 | 0.84 | CTSS (0.39) | CTSSCTSKAAK1RENCTSD | |
| SCHEMBL7286725 | 0.83 | REN (0.42) | CTSSCTSKAAK1RENCTSD | |
| SCHEMBL7281017 | 0.83 | CTSS (0.40) | CTSSCTSKAAK1RENCTSD | |
| SCHEMBL7280905 | 0.83 | CTSS (0.40) | CTSSCTSKAAK1RENCTSD | |
| SCHEMBL7280391 | 0.81 | CTSS (0.39) | CTSSCTSKAAK1RENCTSD | |
| SCHEMBL7290628 | 0.81 | REN (0.41) | CTSSCTSKRENCACNA1B | |
| SCHEMBL7281106 | 0.80 | CTSK (0.48) | CTSSCTSKAAK1RENCTSD | |
| SCHEMBL7293395 | 0.79 | CTSS (0.39) | CTSSCTSKAAK1RENCTSD | |
| SCHEMBL7280957 | 0.78 | CTSS (0.42) | CTSSCTSKAAK1RENCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307837-A2 | Renin-inhibiting peptidyl heterocycles | ABBOTT LABORATORIES (US) | 1989-03-22 | — | — | EP | disclosed |