Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 7/20 | 0.46 |
| ▸ | CACNA1D | Q01668 | 7/20 | 0.46 |
| ▸ | CACNA1S | Q13698 | 7/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 7/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7271592 | 0.92 | ABCC1 (0.47) | CACNA1FCACNA1DCACNA1SCACNA1CABCC1 | |
| SCHEMBL7279891 | 0.85 | CACNA1F (0.46) | CACNA1FCACNA1DCACNA1SCACNA1CABCC1 | |
| SCHEMBL7279866 | 0.84 | ACHE (0.51) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL3038503 | 0.78 | ABCC1 (0.72) | CACNA1FCACNA1DCACNA1SCACNA1CABCC1 | |
| SCHEMBL7279034 | 0.77 | LMNA (0.52) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL7273162 | 0.76 | ACHE (0.52) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL7272944 | 0.75 | CACNA1F (0.54) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL7278558 | 0.74 | ALDH1A1 (0.46) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL7271774 | 0.74 | CYP1A2 (0.61) | CACNA1FCACNA1DCACNA1SCACNA1CTSHR | |
| SCHEMBL28435076 | 0.74 | ADORA3 (0.67) | CACNA1FCACNA1DCACNA1SCACNA1CABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114273-B1 | NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1991-11-06 | — | — | EP | disclosed |
| US-4954508-A | HYPOTENSIVE | GRUPPO LEPETIT S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |
| EP-0114273-A1 | New pharmacologically active pyrazolopyridines | GRUPPO LEPETIT S.p.A. (IT) | 1984-08-01 | — | — | EP | disclosed |