Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MITF | O75030 | 2/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7282159 | 0.79 | PRMT1 (0.57) | PRMT1NPC1RAB9AMITFXBP1 | |
| SCHEMBL11387426 | 0.77 | ALDH1A1 (0.47) | NPC1RAB9AALDH1A1SMN1; SMN2HTT | |
| SCHEMBL10837614 | 0.76 | SMN1; SMN2 (0.46) | NPC1ALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL7435728 | 0.76 | ALDH1A1 (0.46) | NPC1ALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL7750891 | 0.76 | ALOX12 (0.47) | GAANPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL9478167 | 0.75 | ALDH1A1 (0.46) | RAB9AALDH1A1SMN1; SMN2HTTCA1 | |
| SCHEMBL10933393 | 0.74 | HSD17B3 (0.39) | ALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL7290905 | 0.74 | POLB (0.71) | GAANPC1RAB9AMITFXBP1 | |
| SCHEMBL9081388 | 0.74 | NPC1 (0.76) | PRMT1NPC1RAB9AMITFXBP1 | |
| SCHEMBL1031451 | 0.73 | HDAC3 (0.60) | PRMT1NPC1RAB9AMITFXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567264-A | ADRENERGIC BLOCKING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |
| EP-0126449-A1 | Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry | SYNTEX (U.S.A.) INC. (US) | 1984-11-28 | — | — | EP | disclosed |