Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 2/20 | 0.30 |
| ▸ | FNTA | P49354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7283417 | 0.88 | HTR1A (0.37) | CYP19A1CYP11B1CYP11B2HTR1ADRD4 | |
| SCHEMBL7275123 | 0.86 | AR (0.36) | CYP19A1CYP11B1CYP11B2HTR1ADRD4 | |
| SCHEMBL7274156 | 0.86 | ABCB1 (0.42) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL7283159 | 0.86 | ABCB1 (0.42) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL7282764 | 0.86 | ABCB1 (0.42) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL7283267 | 0.85 | HPGD (0.34) | CYP19A1CYP11B1CYP11B2HTR1ADRD4 | |
| SCHEMBL7282767 | 0.85 | HRH3 (0.40) | CYP19A1CYP11B1CYP11B2HTR1ADRD4 | |
| SCHEMBL7282205 | 0.83 | ABCB1 (0.41) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL7274497 | 0.83 | MRGPRX4 (0.36) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL7281425 | 0.82 | CYP11B1 (0.33) | CYP11B1CYP11B2HTR1ADRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483667-B1 | Cyclic imino derivatives, process for their preparation and drugs containing them | THOMAE GMBH DR K (DE) | 1998-02-04 | — | — | EP | disclosed |
| US-5591769-A | PYRROLIDINE DERIVATIVES; ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1997-01-07 | — | — | US | disclosed |
| US-5541343-A | ANTIAGGLOMERANTS FOR CELLS OR ANTICOAGULANTS | KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
| EP-0483667-A2 | Cyclic imino derivatives, process for their preparation and drugs containing them | Dr. Karl Thomae GmbH (DE) | 1992-05-06 | — | — | EP | disclosed |