Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 2/20 | 0.39 |
| ▸ | REN | P00797 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10582459 | 0.75 | METAP1 (0.50) | METAP1METAP2SIGMAR1CYP1A2 | |
| SCHEMBL7334866 | 0.75 | METAP1 (0.50) | METAP1METAP2SIGMAR1CYP1A2 | |
| SCHEMBL13724320 | 0.75 | METAP1 (0.58) | METAP1METAP2SIGMAR1CYP1A2 | |
| SCHEMBL7266597 | 0.74 | METAP2 (0.41) | METAP1METAP2REN | |
| SCHEMBL7266321 | 0.74 | METAP2 (0.44) | METAP1METAP2RENCYP1A2 | |
| SCHEMBL7266293 | 0.74 | METAP2 (0.44) | METAP1METAP2RENCYP1A2 | |
| SCHEMBL7264762 | 0.74 | METAP2 (0.41) | METAP1METAP2REN | |
| SCHEMBL7283388 | 0.72 | TP53 (0.36) | — | |
| SCHEMBL9504627 | 0.72 | METAP1 (0.42) | METAP1METAP2SIGMAR1CYP1A2 | |
| SCHEMBL7852214 | 0.72 | METAP2 (0.50) | METAP1METAP2RENSIGMAR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0483403-A1 | Derivatives of amino acids as inhibitors of renin, methods for their preparation, medicaments containing them and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-05-06 | — | — | EP | disclosed |