Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 3/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | BUB1 | O43683 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294516 | 0.82 | CDC7 (0.52) | CDC7MAPKAPK2MAPK9DYRK1APIM1 | |
| SCHEMBL7286094 | 0.82 | CDC7 (0.52) | CDC7MAPKAPK2MAPK9DYRK1APIM1 | |
| SCHEMBL7294857 | 0.78 | MAPKAPK2 (0.50) | CDC7MAPKAPK2MAPK9DYRK1AKDM4E | |
| SCHEMBL7283655 | 0.78 | PARP1 (0.46) | CDC7MAPKAPK2MAPK9DYRK1APIM1 | |
| SCHEMBL5830904 | 0.77 | DYRK1A (0.68) | DYRK1AFEN1BUB1KDM4EMEN1 | |
| SCHEMBL28370434 | 0.76 | KDM4E (0.60) | FEN1KDM4EMEN1CYP1A2HPGD | |
| SCHEMBL1286 | 0.74 | KDM4E (0.58) | CDC7BUB1KDM4EMEN1CYP1A2 | |
| SCHEMBL1658817 | 0.74 | CDC7 (0.45) | CDC7MAPKAPK2MAPK9PIM1KDM4E | |
| SCHEMBL10154880 | 0.74 | NISCH (0.47) | CDC7MAPKAPK2MAPK9DYRK1AKDM4E | |
| SCHEMBL7284065 | 0.72 | PIK3CG (0.47) | CDC7MAPKAPK2MAPK9PIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353983-B1 | Lactam derivatives | GLAXO GROUP LTD (GB) | 1996-05-29 | — | — | EP | disclosed |
| US-5183820-A | Useful for treatment of nausea, vomiting, irritable bowel syndrome and dyspepsia | GLAXO GROUP LIMITED (GB) | 1993-02-02 | — | — | US | disclosed |
| EP-0353983-A2 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1990-02-07 | — | — | EP | disclosed |