Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.52 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.42 |
| ▸ | CCND1 | P24385 | 2/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.42 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.42 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.42 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10154880 | 0.91 | NISCH (0.47) | CDC7NISCHPARP10PARP11KDM4E | |
| SCHEMBL7294516 | 0.82 | CDC7 (0.52) | CDC7PARP10PARP11KDM4EDYRK1A | |
| SCHEMBL7283436 | 0.82 | CDC7 (0.52) | CDC7KDM4EDYRK1AMEN1CYP1A2 | |
| SCHEMBL7294857 | 0.78 | MAPKAPK2 (0.50) | CDC7KDM4ECDK4CCND1DYRK1A | |
| SCHEMBL1286 | 0.74 | KDM4E (0.58) | CDC7NISCHKDM4ECDK4CCND1 | |
| SCHEMBL1658817 | 0.74 | CDC7 (0.45) | CDC7KDM4EHSD17B10CDK4CCND1 | |
| SCHEMBL7284065 | 0.72 | PIK3CG (0.47) | CDC7MAPK9MAPKAPK2PIM1PIM2 | |
| SCHEMBL4265286 | 0.72 | CLEC4M (0.50) | CDC7KDM4ECDK2DYRK1AKMT2A | |
| SCHEMBL21612903 | 0.70 | PARP10 (0.54) | PARP10PARP11DYRK1ATUBB4ATUBB | |
| SCHEMBL16943062 | 0.70 | CDC7 (0.52) | CDC7PARP10PARP11CDK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353983-B1 | Lactam derivatives | GLAXO GROUP LTD (GB) | 1996-05-29 | — | — | EP | disclosed |
| US-5183820-A | Useful for treatment of nausea, vomiting, irritable bowel syndrome and dyspepsia | GLAXO GROUP LIMITED (GB) | 1993-02-02 | — | — | US | disclosed |
| EP-0353983-A2 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1990-02-07 | — | — | EP | disclosed |