Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.46 |
| ▸ | RPA1 | P27694 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7286094 | 0.82 | CDC7 (0.52) | CDC7PARP10PARP11DYRK1AAHR | |
| SCHEMBL7283436 | 0.82 | CDC7 (0.52) | CDC7DYRK1AMAPK9MAPKAPK2KDM4E | |
| SCHEMBL7294857 | 0.81 | MAPKAPK2 (0.50) | CDC7MCL1DYRK1AMAPK9MAPKAPK2 | |
| SCHEMBL1658817 | 0.77 | CDC7 (0.45) | CDC7PARP1MAPK9MAPKAPK2KDM4E | |
| SCHEMBL4265286 | 0.77 | CLEC4M (0.50) | CDC7DYRK1AKDM4EKDRPIM1 | |
| SCHEMBL6926709 | 0.77 | DYRK1A (0.68) | RPA1MCL1DYRK1AAHRKDM4E | |
| SCHEMBL6352557 | 0.76 | KDM4E (0.60) | PARP1PARP10PARP11DYRK1AKDM4E | |
| SCHEMBL1286 | 0.74 | KDM4E (0.58) | CDC7PARP1KDM4EKDRMEN1 | |
| SCHEMBL10154880 | 0.74 | NISCH (0.47) | CDC7PARP10PARP11DYRK1AMAPK9 | |
| SCHEMBL7284065 | 0.72 | PIK3CG (0.47) | CDC7MAPK9MAPKAPK2PIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353983-B1 | Lactam derivatives | GLAXO GROUP LTD (GB) | 1996-05-29 | — | — | EP | disclosed |
| US-5183820-A | Useful for treatment of nausea, vomiting, irritable bowel syndrome and dyspepsia | GLAXO GROUP LIMITED (GB) | 1993-02-02 | — | — | US | disclosed |
| EP-0353983-A2 | Lactam derivatives | GLAXO GROUP LIMITED (GB) | 1990-02-07 | — | — | EP | disclosed |