Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CDC25B | P30305 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL723523 | 0.76 | GAA (0.54) | ALDH1A1GAACYP3A4KDM4EMAPT | |
| SCHEMBL7293668 | 0.75 | CYP3A4 (0.50) | PRMT6ALDH1A1ADRA1DTP53THRB | |
| SCHEMBL25128132 | 0.73 | TP53 (0.44) | PRMT6ALDH1A1ADRA1DTP53THRB | |
| SCHEMBL7286076 | 0.72 | PTGS1 (0.41) | ADRA1DGAACYP3A4KDM4EMAPT | |
| SCHEMBL27052063 | 0.71 | NOS3 (0.51) | PRMT6ALDH1A1ADRA1DTP53THRB | |
| SCHEMBL7375963 | 0.70 | PRMT6 (0.43) | PRMT6ALDH1A1ADRA1DTP53THRB | |
| SCHEMBL7293028 | 0.70 | RAB9A (0.61) | ALDH1A1TP53GAACYP3A4KDM4E | |
| SCHEMBL10017405 | 0.70 | PRMT6 (0.65) | PRMT6ALDH1A1ADRA1DTP53THRB | |
| SCHEMBL8515024 | 0.70 | GAA (0.47) | ALDH1A1GAACYP3A4KDM4EMAPT | |
| SCHEMBL14259479 | 0.69 | TP53 (0.46) | PRMT6ALDH1A1ADRA1DTP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353032-B1 | 1,5-BENZOTHIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CARDIOVASCULAR DISORDERS | Sankyo Company Limited (JP) | 1992-02-26 | — | — | EP | disclosed |
| US-5002942-A | Calcium channel blockers for cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1991-03-26 | — | — | US | disclosed |
| EP-0353032-A1 | 1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders | Sankyo Company Limited (JP) | 1990-01-31 | — | — | EP | disclosed |