Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | PNP | P00491 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28047877 | 0.84 | KCNH2 (0.46) | PTGS1PTGS2TAAR1L3MBTL1MEN1 | |
| SCHEMBL723523 | 0.78 | GAA (0.54) | MEN1KMT2APOLBCYP3A4KDM4E | |
| SCHEMBL7294757 | 0.74 | CYP3A4 (0.52) | PTGS1PTGS2TAAR1L3MBTL1MEN1 | |
| SCHEMBL27071197 | 0.74 | MAOA (0.46) | PTGS1PTGS2TAAR1L3MBTL1CYP3A4 | |
| SCHEMBL7285039 | 0.73 | CALM1 (0.48) | MEN1KMT2APOLBCYP3A4KDM4E | |
| SCHEMBL7283943 | 0.72 | PRMT6 (0.41) | MEN1KMT2APOLBCYP3A4KDM4E | |
| SCHEMBL29337530 | 0.71 | LTA4H (0.57) | PTGS1PTGS2TAAR1MEN1KMT2A | |
| SCHEMBL8515024 | 0.71 | GAA (0.47) | MEN1KMT2APOLBCYP3A4KDM4E | |
| SCHEMBL6222184 | 0.70 | CA1 (0.57) | PTGS1PTGS2TAAR1KDM4EGAA | |
| SCHEMBL9625952 | 0.70 | CYP2D6 (0.49) | PTGS1PTGS2TAAR1CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0353032-B1 | 1,5-BENZOTHIAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CARDIOVASCULAR DISORDERS | Sankyo Company Limited (JP) | 1992-02-26 | — | — | EP | disclosed |
| US-5002942-A | Calcium channel blockers for cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1991-03-26 | — | — | US | disclosed |
| EP-0353032-A1 | 1,5-benzothiazepine derivatives, their preparation and their use in the treatment of cardiovascular disorders | Sankyo Company Limited (JP) | 1990-01-31 | — | — | EP | disclosed |