Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 4/20 | 0.43 |
| ▸ | CTSD | P07339 | 8/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284894 | 0.84 | REN (0.43) | RENMETAP2CPB2METAP1 | |
| SCHEMBL7284964 | 0.84 | REN (0.43) | RENMETAP2CPB2METAP1 | |
| SCHEMBL7284908 | 0.84 | REN (0.43) | RENMETAP2CPB2METAP1 | |
| SCHEMBL7284898 | 0.84 | REN (0.43) | RENMETAP2CPB2METAP1 | |
| Hydrochloric Acid SCHEMBL7285772 | 0.83 | REN (0.43) | RENMETAP2CPB2METAP1 | |
| Hydrochloric Acid SCHEMBL7285775 | 0.83 | REN (0.43) | RENMETAP2CPB2METAP1 | |
| Hydrochloric Acid SCHEMBL7285779 | 0.83 | REN (0.43) | RENMETAP2CPB2METAP1 | |
| Hydrochloric Acid SCHEMBL7351019 | 0.83 | REN (0.43) | RENMETAP2CPB2METAP1 | |
| SCHEMBL10353206 | 0.78 | METAP2 (0.44) | RENMETAP2METAP1 | |
| SCHEMBL7358079 | 0.78 | METAP2 (0.44) | RENMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5268374-A | Containing both amide and hydroxy groups | ABBOTT LABORATORIES (US) | 1993-12-07 | — | — | US | disclosed |
| EP-0437508-A4 | NON-PEPTIDE RENIN INHIBITORS | — | 1991-11-06 | — | — | EP | disclosed |
| EP-0437508-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1991-07-24 | — | — | EP | disclosed |
| EP-0364804-A1 | Non-peptide renin inhibitors | ABBOTT LABORATORIES (US) | 1990-04-25 | — | — | EP | disclosed |
| WO-1990003971-A1 | NON-PEPTIDE RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1990-04-19 | — | — | WO | disclosed |