Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | LIPE | Q05469 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1190605 | 0.80 | MAPT (0.52) | MAPTTDP1L3MBTL1LIPEMAPK1 | |
| SCHEMBL21647153 | 0.79 | LMNA (0.44) | MAPTTDP1L3MBTL1LIPEMAPK1 | |
| SCHEMBL27923841 | 0.79 | TDP1 (0.50) | MAPTTDP1L3MBTL1LIPEMAPK1 | |
| SCHEMBL28006544 | 0.79 | LTA4H (0.53) | MAPTTDP1L3MBTL1LIPEMAPK1 | |
| SCHEMBL3211927 | 0.79 | MAPT (0.50) | MAPTTDP1L3MBTL1LIPEMAPK1 | |
| SCHEMBL510440 | 0.79 | MAPT (0.50) | MAPTTDP1L3MBTL1LIPEMAPK1 | |
| SCHEMBL7293597 | 0.79 | MAPT (0.59) | MAPTTDP1L3MBTL1LIPEMAPK1 | |
| SCHEMBL11752081 | 0.78 | RXRA (0.48) | MAPTTDP1L3MBTL1LIPEMAPK1 | |
| SCHEMBL4130095 | 0.78 | MAPT (0.59) | MAPTTDP1L3MBTL1LIPEMAPK1 | |
| SCHEMBL8939743 | 0.77 | MAPT (0.49) | MAPTTDP1L3MBTL1LIPEMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347766-B1 | 4,5,7,8-Tetrahydro-6H-thiazolo[5,4-d]azepines, their preparation and their use as medicaments | THOMAE GMBH DR K (DE) | 1994-05-25 | — | — | EP | disclosed |
| US-5068325-A | Dopaminergic systems as hypotensives, sedatives, antitussives and/or antiphlogistics | KARL THOMAE GMBH (DE) | 1991-11-26 | — | — | US | disclosed |
| EP-0347766-A2 | 4,5,7,8-Tetrahydro-6H-thiazolo[5,4-d]azepines, their preparation and their use as medicaments | Dr. Karl Thomae GmbH (DE) | 1989-12-27 | — | — | EP | disclosed |