Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | LIPE | Q05469 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 6/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8339251 | 0.85 | MAPT (0.51) | MAPTL3MBTL1LIPEMAPK1TDP1 | |
| SCHEMBL8939785 | 0.85 | HTR1A (0.42) | MAPTL3MBTL1LIPEMAPK1HTR1A | |
| SCHEMBL28166152 | 0.81 | LIPE (0.44) | MAPTL3MBTL1LIPEMAPK1TDP1 | |
| SCHEMBL8939734 | 0.81 | HPGD (0.41) | MAPTL3MBTL1MAPK1HTR1AADRA1A | |
| SCHEMBL8939792 | 0.81 | CYP1A2 (0.46) | L3MBTL1DRD2LTA4HSMN1; SMN2 | |
| SCHEMBL8859963 | 0.81 | LTA4H (0.44) | HTR1ALTA4HADRA1DADRA1AADRA1B | |
| SCHEMBL1190605 | 0.79 | MAPT (0.52) | MAPTL3MBTL1LIPEMAPK1TDP1 | |
| SCHEMBL510440 | 0.77 | MAPT (0.50) | MAPTL3MBTL1LIPEMAPK1TDP1 | |
| SCHEMBL7285309 | 0.77 | MAPT (0.50) | MAPTL3MBTL1LIPEMAPK1TDP1 | |
| SCHEMBL7293597 | 0.77 | MAPT (0.59) | MAPTL3MBTL1LIPEMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5516797-A | SUPPRESSING GRAFT REJECTION | VERTEX PHARMACEUTICALS, INCORPORATED (US) | 1996-05-14 | — | — | US | disclosed |
| US-5330993-A | Immunosuppressive compounds | VERTEX PHARMACEUTICALS, INC. (US) | 1994-07-19 | — | — | US | disclosed |