Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8650351 | 0.83 | KMT2A (0.52) | KMT2AMEN1SMN1; SMN2HRH3SIGMAR1 | |
| SCHEMBL7291775 | 0.83 | ITGB3 (0.61) | KMT2ASMN1; SMN2ITGB3ITGA2BHRH3 | |
| SCHEMBL7291497 | 0.83 | KMT2A (0.51) | KMT2AMEN1SMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL8880311 | 0.82 | ITGB3 (0.48) | SMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL8650355 | 0.82 | KMT2A (0.51) | KMT2AMEN1SMN1; SMN2HRH3SIGMAR1 | |
| SCHEMBL8379701 | 0.81 | ITGB3 (0.52) | ITGB3ITGA2BHRH3SIGMAR1RORC | |
| SCHEMBL7284564 | 0.81 | ITGB3 (0.52) | ITGB3ITGA2BHRH3SIGMAR1RORC | |
| SCHEMBL8382436 | 0.81 | ITGB3 (0.47) | ITGB3ITGA2BHRH3RORC | |
| SCHEMBL8379264 | 0.79 | KMT2A (0.45) | KMT2AMEN1SMN1; SMN2ITGB3ITGA2B | |
| SCHEMBL8379876 | 0.79 | PAX8 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656348-B1 | Aceric acid derivatives as medicaments | HOFFMANN LA ROCHE (CH) | 2000-05-03 | — | — | EP | disclosed |
| US-5973188-A | Acetic acid derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-10-26 | — | — | US | disclosed |
| EP-0656348-A2 | Aceric acid derivatives as medicaments | F. HOFFMANN-LA ROCHE AG (CH) | 1995-06-07 | — | — | EP | disclosed |