Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7288071 | 0.85 | KMT2A (0.43) | LMNASMN1; SMN2GAANPSR1MEN1 | |
| SCHEMBL7294604 | 0.85 | PDE4A (0.39) | SMN1; SMN2GAANPSR1MEN1KMT2A | |
| SCHEMBL7291459 | 0.82 | CNR2 (0.36) | SMN1; SMN2MAPTTP53TSHR | |
| SCHEMBL7289645 | 0.81 | GAA (0.35) | SMN1; SMN2GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL7292065 | 0.80 | HTT (0.37) | SMN1; SMN2GAAHTTMEN1KMT2A | |
| SCHEMBL10558483 | 0.79 | GLA (0.41) | LMNASMN1; SMN2GAAHTTMEN1 | |
| SCHEMBL7286210 | 0.79 | GABRP (0.41) | LMNASMN1; SMN2HTTNPSR1MEN1 | |
| SCHEMBL10569584 | 0.79 | KDM4E (0.38) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL7289330 | 0.79 | MIF (0.34) | KDM4E | |
| SCHEMBL7287387 | 0.79 | GAA (0.34) | SMN1; SMN2GAAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4849421-A | SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1989-07-18 | — | — | US | disclosed |
| EP-0281045-A1 | Benzothiepino (5,4-c) pyridazine compounds and their pharmaceutical uses | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1988-09-07 | — | — | EP | disclosed |