Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL727611 | 0.82 | PDCD1 (0.32) | PDCD1CD274CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL6553563 | 0.77 | CHRNB2 (0.33) | PDCD1CD274CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL16736480 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL8678158 | 0.70 | EDNRB (0.30) | — | |
| Hydrochloric Acid SCHEMBL29424591 | 0.66 | PDCD1 (0.35) | PDCD1CD274CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL3163965 | 0.66 | PDCD1 (0.35) | PDCD1CD274CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL5709184 | 0.66 | PDCD1 (0.35) | PDCD1CD274CHRNB2CHRNA4 | |
| SCHEMBL17074028 | 0.66 | CYP2A6 (0.35) | PDCD1CD274CHRNB2CHRNA4 | |
| SCHEMBL6470879 | 0.65 | PDCD1 (0.37) | PDCD1CD274CHRNB2CHRNA4 | |
| SCHEMBL30013075 | 0.65 | HTR1A (0.36) | PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011525212-A | — | — | 2011-09-15 | — | — | JP | claimed |
| EP-2291419-A2 | POLYMACROMONOMER AND PROCESS FOR PRODUCTION THEREOF | ExxonMobil Chemical Patents Inc. (US) | 2011-03-09 | — | — | EP | claimed |
| US-8431662-B2 | Polymacromonomer and process for production thereof | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2013-04-30 | — | — | US | disclosed |
| EP-1753796-B1 | MULTIPLE CATALYST AND REACTOR SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM | EXXONMOBIL CHEM PATENTS INC (US) | 2011-08-10 | — | — | EP | disclosed |
| EP-2291419-A2 | POLYMACROMONOMER AND PROCESS FOR PRODUCTION THEREOF | ExxonMobil Chemical Patents Inc. (US) | 2011-03-09 | — | — | EP | disclosed |