Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8678158 | 0.84 | EDNRB (0.30) | — | |
| Hydrochloric Acid SCHEMBL6553648 | 0.79 | GPR3 (0.35) | HTR1AALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL728767 | 0.77 | PDCD1 (0.32) | CHRNB2CHRNA4PDCD1CD274 | |
| Hydrochloric Acid SCHEMBL16736480 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL6555254 | 0.71 | MAPT (0.32) | — | |
| Hydrochloric Acid SCHEMBL8679012 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL7251524 | 0.67 | MYC (0.38) | HTR7ALDH1A1 | |
| SCHEMBL2594422 | 0.67 | ALDH1A1 (0.50) | CHRNB2CHRNA4ALDH1A1HSD17B10BCAT2 | |
| SCHEMBL28010330 | 0.66 | PDCD1 (0.35) | CHRNB2CHRNA4PDCD1CD274HTR1A | |
| Hydrochloric Acid SCHEMBL3163965 | 0.66 | PDCD1 (0.35) | CHRNB2CHRNA4PDCD1CD274HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077215-B1 | Asymmetric silicon-bridged metallocenes useful as catalysts in the polymerization of a-olefins, process for their preparation and use of said metallocenes for the polymerization of a-olefins | SOLVAY (BE) | 2004-02-18 | — | — | EP | disclosed |
| EP-1077215-A1 | Asymmetric silicon-bridged metallocenes useful as catalysts in the polymerization of a-olefins, process for their preparation and use of said metallocenes for the polymerization of a-olefins | SOLVAY POLYOLEFINS EUROPE - BELGIUM (Société Anonyme) (BE) | 2001-02-21 | — | — | EP | disclosed |