Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.57 |
| ▸ | ABAT | P80404 | 1/20 | 0.57 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.53 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28621032 | 0.87 | ALDH5A1 (0.54) | ALDH5A1ABATVCAM1ALDH3A1ALDH1A1 | |
| SCHEMBL30208604 | 0.87 | ALDH5A1 (0.54) | ALDH5A1ABATVCAM1ALDH3A1ALDH1A1 | |
| SCHEMBL4575571 | 0.86 | ALDH5A1 (0.62) | ALDH5A1ABATVCAM1ALDH3A1ALDH1A1 | |
| SCHEMBL5882961 | 0.84 | ALDH3A1 (0.58) | ALDH5A1ABATVCAM1ALDH3A1ALDH1A1 | |
| SCHEMBL7003338 | 0.82 | ALDH5A1 (0.53) | ALDH5A1ABATVCAM1ALDH3A1ALDH1A1 | |
| Dimethylamine SCHEMBL7134989 | 0.80 | ALDH3A1 (0.54) | ALDH5A1ABATVCAM1ALDH3A1ALDH1A1 | |
| SCHEMBL5594749 | 0.80 | PLA2G4A (0.50) | ALDH1A1MAPTLMNACYP2C9TTR | |
| SCHEMBL5594752 | 0.80 | PLA2G4A (0.50) | ALDH1A1MAPTLMNACYP2C9TTR | |
| SCHEMBL10335465 | 0.80 | MAPT (0.45) | ALDH1A1MAPTLMNATTRHPGD | |
| SCHEMBL5594757 | 0.80 | PLA2G4A (0.50) | ALDH1A1MAPTLMNACYP2C9TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0406958-B1 | Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1995-03-15 | — | — | EP | disclosed |
| US-5220023-A | Intermediates for inotropic agents | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-06-15 | — | — | US | disclosed |
| US-5120845-A | Treating congestive heart failure | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-06-09 | — | — | US | disclosed |
| US-5043327-A | Treating mammals with congestive heart failure | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-08-27 | — | — | US | disclosed |
| CN-1051560-A | Contractile and relaxing force enhancing 3, 5-dihydroimidazo [2, 1-b ] quinazolin-2 (1H) -one derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1991-05-22 | — | — | CN | disclosed |
| EP-0406958-A2 | Positive inotropic and lusitropic 3,5-dihydroimidazo[2,1-b]quinazolin-2(1H)-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-09 | — | — | EP | disclosed |