Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 9/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9555628 | 0.79 | RAB9A (0.38) | NPC1RAB9ASMN1; SMN2CTSSCTSK | |
| SCHEMBL7278146 | 0.76 | CTSK (0.39) | SMN1; SMN2AAK1CTSSCTSKMAPT | |
| SCHEMBL7275375 | 0.75 | AAK1 (0.41) | AAK1KCNA5TSHR | |
| SCHEMBL7269535 | 0.75 | AAK1 (0.41) | AAK1KCNA5TSHR | |
| SCHEMBL7426619 | 0.70 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2AAK1CTSS | |
| SCHEMBL7269236 | 0.68 | MAPT (0.41) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL7269246 | 0.68 | MAPT (0.41) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL15674460 | 0.68 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2CTSSCTSK | |
| SCHEMBL15697045 | 0.68 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2CTSSCTSK | |
| SCHEMBL15697029 | 0.68 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0376012-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1990-07-04 | — | — | EP | disclosed |