Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7356813 | 0.89 | KEAP1 (0.37) | KEAP1NFE2L2HSP90AA1P2RX7APP | |
| SCHEMBL7291077 | 0.87 | KEAP1 (0.39) | KEAP1NFE2L2HSP90AA1P2RX7APP | |
| SCHEMBL7349497 | 0.83 | CA2 (0.39) | KEAP1NFE2L2HSP90AA1P2RX7APP | |
| SCHEMBL7356815 | 0.80 | CA2 (0.42) | KEAP1NFE2L2HSP90AA1P2RX7APP | |
| SCHEMBL19422050 | 0.80 | HSP90AA1 (0.37) | HSP90AA1P2RX7APPNPC1KMT2A | |
| SCHEMBL7291080 | 0.79 | CA2 (0.44) | KEAP1NFE2L2HSP90AA1P2RX7APP | |
| SCHEMBL4683019 | 0.74 | NFE2L2 (0.58) | KEAP1NFE2L2NPC1 | |
| SCHEMBL5220679 | 0.71 | HSP90AA1 (0.39) | HSP90AA1P2RX7CYP2D6 | |
| SCHEMBL29579947 | 0.71 | HSP90AA1 (0.39) | HSP90AA1P2RX7 | |
| SCHEMBL4066547 | 0.71 | HSP90AA1 (0.39) | HSP90AA1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652247-A | VASOPRESSIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD (JP) | 1997-07-29 | — | — | US | disclosed |
| US-5436254-A | Vaopressin antagonists | OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0602209-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-22 | — | — | EP | disclosed |
| EP-0382185-B1 | Carbostyril derivatives | OTSUKA PHARMA CO LTD (JP) | 1994-06-15 | — | — | EP | disclosed |
| WO-1994001113-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1994-01-20 | — | — | WO | disclosed |
| US-5225402-A | Vasopressin antagonist, vasodilation, hypotensive, diuretics and anticoagulants | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-06 | — | — | US | disclosed |
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |