Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9828576 | 0.86 | HRH4 (0.39) | ADRA2ACYP2D6OPRM1SLC6A3KCNH2 | |
| Hydrochloric Acid SCHEMBL9827176 | 0.85 | GRIN2D (0.40) | ADRA2ACYP2D6OPRM1SLC6A3KCNH2 | |
| SCHEMBL7288663 | 0.81 | SCN5A (0.34) | ADRA2AADRA2BCHRM2CHRM1CYP2D6 | |
| SCHEMBL9828326 | 0.80 | HRH4 (0.33) | KCNH2ALDH1A1 | |
| SCHEMBL9828851 | 0.80 | GBA1 (0.38) | CYP2D6CYP1A2TSHRPKMSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9827568 | 0.79 | GRIN2D (0.33) | KCNH2ALDH1A1 | |
| SCHEMBL7288384 | 0.79 | SCN5A (0.34) | ADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL9827508 | 0.79 | GRIN2D (0.36) | CYP2D6KCNH2TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL9828412 | 0.76 | CHRM2 (0.46) | ADRA2AADRA2BCHRM2CHRM1CYP2D6 | |
| Hydrochloric Acid SCHEMBL9827919 | 0.75 | LMNA (0.47) | ADRA2AADRA2BCHRM2CHRM1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0262448-B1 | IMIDAZOLYLGUANIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | HEUMANN PHARMA GMBH & CO (DE) | 1991-12-18 | — | — | EP | disclosed |