Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.72 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777934 | 0.85 | ALDH1A1 (0.57) | POLBMEN1KMT2AALOX15TSHR | |
| SCHEMBL27935848 | 0.84 | MEN1 (0.61) | POLBMEN1KMT2AALOX15RAB9A | |
| SCHEMBL9032081 | 0.83 | MEN1 (0.52) | POLBMEN1KMT2AALOX15TSHR | |
| Hydrochloric Acid SCHEMBL8554173 | 0.83 | ALDH1A1 (0.55) | POLBMEN1KMT2AALOX15TSHR | |
| SCHEMBL7438110 | 0.82 | POLB (0.74) | POLBMEN1KMT2AALOX15TSHR | |
| Water SCHEMBL9367224 | 0.79 | MEN1 (0.48) | POLBMEN1KMT2AALOX15TSHR | |
| SCHEMBL7278718 | 0.79 | ALDH1A1 (0.62) | POLBMEN1KMT2ATSHRNPC1 | |
| SCHEMBL9031774 | 0.78 | ALDH1A1 (0.53) | POLBMEN1KMT2AALOX15TSHR | |
| SCHEMBL7705614 | 0.78 | POLB (0.55) | POLBMEN1KMT2AALOX15TSHR | |
| SCHEMBL1778375 | 0.77 | ALDH1A1 (0.49) | POLBMEN1KMT2AALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4567264-A | ADRENERGIC BLOCKING AGENTS | SYNTEX (U.S.A.) INC. (US) | 1986-01-28 | — | — | US | disclosed |
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |
| EP-0126449-A1 | Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry | SYNTEX (U.S.A.) INC. (US) | 1984-11-28 | — | — | EP | disclosed |