Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 11/20 | 0.34 |
| ▸ | NPC1 | O15118 | 5/20 | 0.33 |
| ▸ | RAB9A | P51151 | 4/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.31 |
| ▸ | CTSB | P07858 | 2/20 | 0.31 |
| ▸ | CTSS | P25774 | 2/20 | 0.31 |
| ▸ | CTSK | P43235 | 2/20 | 0.31 |
| ▸ | PRSS8 | Q16651 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276163 | 0.91 | ELANE (0.39) | ELANENPC1RAB9ACTSLCTSB | |
| SCHEMBL7287872 | 0.87 | NPC1 (0.33) | NPC1RAB9A | |
| SCHEMBL9744946 | 0.87 | ELANE (0.47) | ELANENPC1RAB9A | |
| SCHEMBL7289208 | 0.83 | ELANE (0.47) | ELANENPC1RAB9A | |
| SCHEMBL7286288 | 0.78 | FAAH (0.39) | ELANE | |
| SCHEMBL9744899 | 0.78 | NPC1 (0.35) | ELANENPC1RAB9A | |
| SCHEMBL7004719 | 0.76 | NPC1 (0.37) | ELANENPC1RAB9A | |
| SCHEMBL7279122 | 0.76 | F2 (0.37) | NPC1RAB9A | |
| SCHEMBL6449506 | 0.75 | PREP (0.35) | ELANE | |
| SCHEMBL7285860 | 0.75 | NPC1 (0.39) | ELANENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0291234-B1 | Peptidic human leukocyte elastase (HLE) inhibitors | ZENECA INC (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5164371-A | HETEROCYCLIC KETONES | ICI AMERICAS INC. (US) | 1992-11-17 | — | — | US | disclosed |