SCHEMBL7288809

SCHEMBL7288809

O=C(O)COC[C@@H]1CCCN(C(=O)O)C1

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PTGIR P43119 7/20 0.37
PTGDR Q13258 3/20 0.37
ITGB3 P05106 2/20 0.36
ITGA2B P08514 2/20 0.36
CHRNB2 P17787 2/20 0.35
CHRNA4 P43681 2/20 0.35
CYP4F2 P78329 2/20 0.35
CYP4A11 Q02928 2/20 0.35
ALDH1A1 P00352 1/20 0.35
GRM3 Q14832 3/20 0.34
CHRNB4 P30926 1/20 0.34
CHRNA3 P32297 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7288816 1.00 PTGIR (0.37) PTGIRPTGDRITGB3ITGA2BCHRNB2
SCHEMBL7289057 1.00 PTGIR (0.37) PTGIRPTGDRITGB3ITGA2BCHRNB2
SCHEMBL4434030 0.84 ALDH1A1 (0.43) CHRNB2CHRNA4ALDH1A1GRM3CHRNB4
SCHEMBL7288803 0.82 MEN1 (0.49) ALDH1A1
SCHEMBL3655590 0.81 POLB (0.44) CHRNB2CHRNA4ALDH1A1GRM3CHRNB4
SCHEMBL3778464 0.81 POLB (0.44) CHRNB2CHRNA4ALDH1A1GRM3CHRNB4
SCHEMBL22319904 0.80 PDK1 (0.37) CHRNB2CHRNA4ALDH1A1GRM3CHRNB4
SCHEMBL22366358 0.80 PDK1 (0.37) CHRNB2CHRNA4ALDH1A1GRM3CHRNB4
SCHEMBL8578265 0.80 RAB9A (0.40) CHRNB2CHRNA4CYP4F2CYP4A11ALDH1A1
SCHEMBL8574641 0.80 PDK1 (0.43) CYP4F2CYP4A11ALDH1A1GRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0928793-B1 Thiazole derivatives HOFFMANN LA ROCHE (CH) 2002-05-15 EP disclosed
US-6001855-A REACTING A THIAZOLE DERIVATIVE AND A CYCLIC AMINE DERIVATIVE; INHIBITS BINDING OF ADHESIVE PROTEINS TO THE SURFACE OF DIFFERENT TYPES OF CELL AND ACCORDINGLY INFLUENCE CELL-CELL AND CELL-MATRIX INTERACTIONS HOFFMAN-LA ROCHE INC. (US) 1999-12-14 US disclosed
EP-0928793-A1 Thiazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 1999-07-14 EP disclosed