Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CASR | P41180 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | FNTA | P49354 | 1/20 | 0.53 |
| ▸ | FNTB | P49356 | 1/20 | 0.53 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.53 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.53 |
| ▸ | ANPEP | P15144 | 1/20 | 0.52 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.52 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7289943 | 1.00 | ALDH1A1 (0.56) | ALDH1A1CASRRAB9AKMT2ANPC1 | |
| SCHEMBL10708877 | 0.87 | SLC7A5 (0.64) | ALDH1A1CASRRAB9AKMT2ALNPEP | |
| SCHEMBL28279157 | 0.85 | BACE1 (0.63) | RAB9AKMT2ANPC1MEN1HDAC8 | |
| SCHEMBL2312361 | 0.85 | BACE1 (0.63) | RAB9AKMT2ANPC1MEN1HDAC8 | |
| SCHEMBL2312372 | 0.85 | BACE1 (0.63) | RAB9AKMT2ANPC1MEN1HDAC8 | |
| SCHEMBL8130237 | 0.85 | RAB9A (0.70) | ALDH1A1CASRRAB9AKMT2ANPC1 | |
| SCHEMBL10710578 | 0.84 | NOS3 (0.52) | ALDH1A1RAB9ANPC1MAPK1HDAC8 | |
| SCHEMBL7289459 | 0.84 | BACE1 (0.60) | RAB9AKMT2ANPC1FNTAFNTB | |
| SCHEMBL7289465 | 0.84 | BACE1 (0.60) | RAB9AKMT2ANPC1FNTAFNTB | |
| Hydrochloric Acid SCHEMBL5960992 | 0.84 | HDAC8 (0.65) | RAB9AKMT2ANPC1MEN1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4963539-A | TREATING HEART FAILURE, PAIN OR DIARRHEA | E. R. SQUIBB & SONS, INC. (US) | 1990-10-16 | — | — | US | disclosed |
| EP-0306879-A2 | Phosphonate and phosphonamide endopeptidase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1989-03-15 | — | — | EP | disclosed |