Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 3/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.45 |
| ▸ | APAF1 | O14727 | 2/20 | 0.45 |
| ▸ | NSD2 | O96028 | 2/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.45 |
| ▸ | TDP2 | O95551 | 1/20 | 0.45 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.45 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.45 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.45 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299063 | 0.83 | CASP3 (0.43) | LCKFYNCASP3SENP6APAF1 | |
| SCHEMBL7295979 | 0.83 | PRKDC (0.44) | LCKFYNCASP3SENP6APAF1 | |
| SCHEMBL7290699 | 0.82 | CASP3 (0.42) | LCKFYNCASP3SENP6APAF1 | |
| SCHEMBL7289360 | 0.81 | LCK (0.49) | LCKFYNCASP3SENP6MYC | |
| SCHEMBL8557481 | 0.76 | KDM4E (0.61) | LCKFYNCASP3SENP6ALDH1A1 | |
| SCHEMBL28786825 | 0.75 | LMNA (0.47) | ALDH1A1L3MBTL1KDM4ECA12CA9 | |
| SCHEMBL7380614 | 0.74 | LCK (0.60) | LCKFYNALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL40395 | 0.73 | KDM4C (0.61) | ALDH1A1KDM4EKDM4CMAPT | |
| SCHEMBL30527973 | 0.73 | KDM4C (0.61) | ALDH1A1KDM4EKDM4CMAPT | |
| SCHEMBL1417516 | 0.73 | LCK (0.72) | LCKFYNMYCALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848000-B1 | Pharmaceutical pyridine derivatives, processes for preparing the same and intermediates therefor | TANABE SEIYAKU CO (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-5965730-A | SELECTIVE PHOSPHODIESTEARASE IV INHIBITOR HAVING BRONCHODIALATION AND ANTI-INFLAMMATORY ACTIVITY; PROPHYLAXIS AND TREATMENT OF ASTHMA | TANABE SEIYAKU CO., LTD. (JP) | 1999-10-12 | — | — | US | disclosed |
| EP-0848000-A1 | Pharmaceutical pyridine derivatives, processes for preparing the same and intermediates therefor | TANABE SEIYAKU CO., LTD. (JP) | 1998-06-17 | — | — | EP | disclosed |