Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 4/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.42 |
| ▸ | APAF1 | O14727 | 2/20 | 0.42 |
| ▸ | NSD2 | O96028 | 2/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 3/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297929 | 0.85 | RORB (0.39) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL7289967 | 0.82 | LCK (0.50) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL7381304 | 0.79 | LCK (0.41) | ALDH1A1CYP1A2CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL7295979 | 0.79 | PRKDC (0.44) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL7380165 | 0.74 | TUBB1 (0.49) | LMNA | |
| SCHEMBL16773953 | 0.73 | ACHE (0.40) | CASP3SENP6SENP8SENP7APAF1 | |
| SCHEMBL28786825 | 0.71 | LMNA (0.47) | ALDH1A1L3MBTL1LMNAMAPT | |
| SCHEMBL29584593 | 0.67 | KDM4E (0.60) | ALDH1A1L3MBTL1TSHRHPGDMAPT | |
| SCHEMBL46685 | 0.67 | KDM4E (0.60) | ALDH1A1L3MBTL1TSHRHPGDMAPT | |
| SCHEMBL16691026 | 0.67 | ACHE (0.35) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0848000-B1 | Pharmaceutical pyridine derivatives, processes for preparing the same and intermediates therefor | TANABE SEIYAKU CO (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-5965730-A | SELECTIVE PHOSPHODIESTEARASE IV INHIBITOR HAVING BRONCHODIALATION AND ANTI-INFLAMMATORY ACTIVITY; PROPHYLAXIS AND TREATMENT OF ASTHMA | TANABE SEIYAKU CO., LTD. (JP) | 1999-10-12 | — | — | US | disclosed |
| EP-0848000-A1 | Pharmaceutical pyridine derivatives, processes for preparing the same and intermediates therefor | TANABE SEIYAKU CO., LTD. (JP) | 1998-06-17 | — | — | EP | disclosed |