Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.47 |
| ▸ | PDE4A | P27815 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CETP | P11597 | 2/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8357832 | 0.89 | KMT2A (0.48) | KMT2APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7280685 | 0.88 | KMT2A (0.48) | KMT2APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8355692 | 0.88 | KMT2A (0.64) | KMT2APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7283847 | 0.84 | KMT2A (0.46) | KMT2APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL10102249 | 0.81 | KDM4E (0.62) | KMT2AGPR119KDM4EPKMCETP | |
| SCHEMBL4522107 | 0.79 | GPR119 (0.58) | KMT2AGPR119KDM4EPKMCETP | |
| SCHEMBL7290315 | 0.79 | ITGB3 (0.35) | KMT2APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL3658834 | 0.75 | HPGD (0.50) | GPR119KDM4E | |
| SCHEMBL1725187 | 0.73 | PDE4D (0.45) | KMT2APDE4DPDE4APDE4BPDE4C | |
| SCHEMBL5438080 | 0.73 | PDE4D (0.45) | KMT2APDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981531-A | FOR INHIBITING PLATELET AGGREGATION | ZENECA LIMITED (GB) | 1999-11-09 | — | — | US | disclosed |
| EP-0632016-B1 | 1,2-Diacylated hydrazine derivatives and their use as cell adhesion inhibitors | ZENECA LTD (GB) | 1997-04-09 | — | — | EP | disclosed |
| US-5612373-A | ANTICOAGULANTS | ZENECA LIMITED (GB) | 1997-03-18 | — | — | US | disclosed |
| WO-1995000472-A1 | 1,2 DIACYLATED HYDRAZINE DERIVATIVES AND THEIR USE AS ALL ADHESION INHIBITORS | ZENECA LIMITED (GB) | 1995-01-05 | — | — | WO | disclosed |
| EP-0632016-A1 | 1,2-Diacylated hydrazine derivatives and their use as cell adhesion inhibitors | ZENECA LIMITED (GB) | 1995-01-04 | — | — | EP | disclosed |