Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.34 |
| ▸ | CTSB | P07858 | 4/20 | 0.34 |
| ▸ | CTSS | P25774 | 8/20 | 0.34 |
| ▸ | TACR2 | P21452 | 2/20 | 0.30 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.30 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.30 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.30 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.30 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.30 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.30 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.30 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.30 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.30 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.30 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.30 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.30 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.30 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.30 |
| ▸ | PSMB3 | P49720 | 1/20 | 0.30 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7908157 | 0.82 | CTSL (0.39) | CTSLCTSBCTSSTACR2PSMB11 | |
| SCHEMBL26019659 | 0.82 | CTSL (0.39) | CTSLCTSBCTSSTACR2PSMB11 | |
| SCHEMBL7441871 | 0.81 | CTSS (0.53) | CTSLCTSBCTSSTACR2PSMB11 | |
| SCHEMBL9417266 | 0.81 | CTSS (0.53) | CTSLCTSBCTSSTACR2PSMB11 | |
| SCHEMBL9556415 | 0.77 | POLB (0.42) | CTSLCTSBCTSS | |
| SCHEMBL22387822 | 0.77 | CTSL (0.39) | CTSLCTSBCTSSTACR2PSMB11 | |
| SCHEMBL1562598 | 0.74 | POLB (0.44) | CTSLCTSBCTSSCTSKCTSH | |
| SCHEMBL1562599 | 0.74 | POLB (0.44) | CTSLCTSBCTSSCTSKCTSH | |
| SCHEMBL7288070 | 0.74 | POLB (0.44) | CTSS | |
| SCHEMBL10555105 | 0.73 | CTSL (0.56) | CTSLCTSBCTSSTACR2PSMB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0416393-A1 | Peptidyl difluorodiol renin inhibitors | ABBOTT LABORATORIES (US) | 1991-03-13 | — | — | EP | disclosed |
| WO-1989010751-A1 | FUNCTIONALIZED PEPTIDYL AMINODIOLS AND -TRIOLS | ABBOTT LABORATORIES (US) | 1989-11-16 | — | — | WO | disclosed |
| EP-0341602-A2 | Renin-inhibiting functionalized peptidyl aminodiols and - triols | ABBOTT LABORATORIES (US) | 1989-11-15 | — | — | EP | disclosed |
| EP-0307837-A2 | Renin-inhibiting peptidyl heterocycles | ABBOTT LABORATORIES (US) | 1989-03-22 | — | — | EP | disclosed |