Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.42 |
| ▸ | CTSB | P07858 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 7/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | CTSH | P09668 | 1/20 | 0.38 |
| ▸ | CTSC | P53634 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1562599 | 1.00 | POLB (0.44) | POLBPKMSMN1; SMN2CTSLCTSB | |
| SCHEMBL10555105 | 0.89 | CTSL (0.56) | POLBCTSLCTSBCTSSCTSK | |
| SCHEMBL27965028 | 0.84 | NPPA (0.41) | — | |
| SCHEMBL1852181 | 0.84 | NPPA (0.41) | — | |
| SCHEMBL25269738 | 0.83 | MMP1 (0.42) | PKMSMN1; SMN2PIN1KMT2A | |
| SCHEMBL25218367 | 0.83 | MMP1 (0.42) | PKMSMN1; SMN2PIN1KMT2A | |
| SCHEMBL10337293 | 0.83 | CTSS (0.41) | POLBSMN1; SMN2CTSLCTSBCTSS | |
| SCHEMBL22387822 | 0.82 | CTSL (0.39) | PKMSMN1; SMN2CTSLCTSBCTSS | |
| SCHEMBL7908157 | 0.82 | CTSL (0.39) | PKMSMN1; SMN2CTSLCTSBCTSS | |
| SCHEMBL26019659 | 0.82 | CTSL (0.39) | PKMSMN1; SMN2CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404356-B1 | METHOD FOR DESIGNING CD10-ACTIVATED PRODRUG COMPOUNDS | MEDAREX INC (US) | 2011-04-06 | — | — | EP | disclosed |